BreakSight is a genomics startup advancing the way cancer drugs are characterized. Our platform analyzes how precision oncology treatments damage DNA at the sequence level. By capturing and sequencing these unique patterns of DNA damage, we help researchers discover new biomarkers—genetic clues that can predict whether a drug will be effective for specific patients.

Currently, many cancer drugs are developed without fully understanding how they impact the genome. BreakSight fills this gap by providing detailed insights into how DNA damage occurs in response to different therapies. These insights can help drug developers make better decisions earlier in the process, potentially improving the success rate of new treatments.

Why are these discoveries pivotal? Data generated by our platform can:
1.	Reveal a drug’s unique effect on the cancer genome and sequence-specific mechanisms of genomic instability
2.	Measure successful drug-target engagement at the genomic level
3.	Pinpoint new DNA sequence biomarkers of drug efficacy that resides in the 98% of the genome left unexplored
4.	Offer deeper DNA damage insights that might identify new therapeutic targets

Our services:

- DDsite
o	Tagging, retrieving, and sequencing DNA double-strand break sites across the genome from cells exposed to treatment(s) that induces DNA damage

- DDinsight
o	Analysis of sequenced data through our stringent analysis pipeline to pinpoint reproducible sites of breakage across the genome
o	Comparison of break sites across conditions

- DDinsight+
o	Uncovering DNA repeats and sequence motifs that are enriched across identified DNA break sites
o	Assessing the overlap of DNA break sites with other genomic elements and characteristics to discovery any significant associations

- DDsite-Cyto
o	Tagging, retrieving, and sequencing DNA double-strand break fragments present specifically in the cytoplasm of cells exposed to treatment(s) that induces DNA damage

BreakSight, Inc.

Org chart

Teams

Offices

BreakSight, Inc.

Org chart

Teams

Offices

Related companies