Lee E. Goldstein

Lee E. Goldstein, M.D., Ph.D. is the co-founder of Cognoptix. Dr. Goldstein’s lab, originally at Brigham & Women’s Hospital, Harvard Medical School, and now at Boston University School of Medicine and Alzheimer’s Disease Research Center, made the seminal discovery that Ab accumulates in the lens of patients with Alzheimer’s disease. This finding is the first evidence of AD-linked Ab pathology outside the brain. Dr. Goldstein confirmed in detailed studies using mass spectroscopy peptide mapping and other techniques that amyloid deposit in the lens of the eye mirror beta-amyloid deposits in the brain. Dr. Goldstein and his team were first to predict, and then identify, identical AD-linked Ab lens pathology in people with Down syndrome, a common chromosomal disease that also results in early-onset Aβ pathology in the brain. He directs the Molecular Aging & Development Laboratory and co-leads the Biomarker Core of the Boston University Alzheimer’s Disease Research Center and Boston University Center for Translational Neuroimaging. Dr. Goldstein’s research provided the foundational science that underpins Cognoptix’ mission. He has received awards from the Alzheimer’s Association, American Federation for Aging Research, Optical Society of America, National Institutes of Health, Harvard Medical School, and Oxford University.