David Epstein

Scientific & Business Advisor at Engine Biosciences

David is a biopharmaceutical leader and executive who has successfully led large and small R&D teams in academic, start-up, mid-size, and global large-pharmaceutical settings. His teams have progressed multiple novel agents through development in oncology, cardiovascular disease, and retinal degeneration.

He is currently the President and CEO of Black Diamond Therapeutics (NASDAQ: BDTX), a precision oncology medicines company pioneering the development of small molecule, tumor-agnostic therapies. Prior to Black Diamond, David was Vice Dean, Innovation & Entrepreneurship, and Associate Professor in Cancer & Stem Cell Biology, at Duke-NUS Medical School, Singapore, where he founded and built Duke-NUS’s Centre for Technology & Development, which has developed a pipeline of innovation projects. Previously, he was Chief Scientific Officer at OSI Pharmaceuticals, a pharmaceutical company acquired by Astellas Pharma, and founder of Archemix Corporation, where he led the advancement of multiple product candidates into the clinical in multiple therapeutic areas.

David earned a Ph.D. in Biochemistry at Brandeis University and completed a joint post-doctoral fellowship, leading a collaboration in protein structure, function, and NMR dynamics between the labs of Steven Benkovic (Penn State) and Peter Wright at The Scripps Research Institute in La Jolla, California. He received a B.Sc. in Chemistry from Lewis & Clark College.