Adrian Thrasher

Advisor at Generation Bio

Adrian Thrasher is professor of pediatric immunology and Wellcome Trust Principal Research Fellow at the University College London Great Ormond Street Institute of Child Health (UCL GOSICH), and Honorary Consultant Pediatric Immunologist at Great Ormond Street Hospital for Children National Health Service Foundation Trust (GOSH). He is the program head of Infection, Immunity and Inflammation at UCL GOSICH and has a longstanding research and clinical interest in the development and application of gene therapy. He is director of the Clinical Gene Therapy Program, and theme leader of the gene stem and cellular therapies theme of the Biomedical Research Centre, at UCL GOSICH/GOSH. Adrian is principal investigator on several clinical trials for immunodeficiency and is director of the clinical gene therapy GMP facility, managing a team of trial coordinators, clinical scientists, and quality systems personnel. His clinical interests are the diagnosis and treatment of patients with primary immunodeficiency. His specialist interests are in the Wiskott-Aldrich Syndrome (WAS), disorders of innate immunity, and autoimmune lymphoproliferative syndrome. His team at UCL GOSICH/GOSH is conducting trials of somatic gene therapy for various forms of PID including X-linked severe combined immunodeficiency (SCID-X1), Chronic granulomatous disease (CGD), Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID), and WAS. Research interests include the pathophysiology of primary immunodeficiency syndromes especially WAS, the actin cytoskeleton in haematopoietic cells, the development of somatic gene therapy, and thymus transplantation. Adrian qualified in medicine in 1986 at St. George’s Hospital Medical School, University of London. He earned his doctorate in 1995 at University College London.


  • Advisor

    Current role

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