The immune system knows how to kill tumors. It just needs to know where to look.
Most solid tumors escape the immune system because they don't look foreign. Checkpoint inhibitors release the brakes, ADCs deliver drugs, and CAR-T engineers immunity from scratch, yet responses stay capped because they ride a single tumor marker that 40-50% of tumors drop under treatment.
IMYUN Pharmaceuticals builds Immune-Tag Conjugates™ (ITCs™), a new category of immunotherapy. Every adult already carries a lifetime of pathogen-primed T-cell memory from vaccines and common infections such as BCG and CMV. ITCs™ redirect that memory, labeling a tumor cell as if it were infected, so the body does what it was already trained to do. We don't build new immunity. We give it a target.
The platform is a modular recombinant protein built on a familiar antibody-based architecture, with the bind-and-internalize logic of ADCs that regulators understand and patients tolerate. We bind the tumor through a surface marker like HER2, tag the cell with a pathogen-derived signal peptide, and pre-existing CD8 memory T-cells recognize the cell as infected and clear it. Selective. Localized. Non-immunosuppressive.
Our lead program, ORION™, is in advanced preclinical development for HER2+ bladder cancer (TCC) and head-and-neck squamous cell carcinoma (HNSCC) — indications where the priming immunity is already standard of care or near-universal in adults, and where tumors drop HER2 under ADC therapy. Epitope spreading keeps ORION working after the marker is gone. Initial in vivo proof of concept is complete, and the definitive head-to-head comparator study is being initiated.
IMYUN brings together seasoned biotech executives, the inventor of the ITC™ platform who built the signal peptide tag system, and a pioneer of the p53/p21 pathway who directs the Legorreta Cancer Center at Brown University.
The immunity is already there. We give it the target.

Imyun Pharmaceuticals

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Imyun Pharmaceuticals

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