We are a Phase 3 ready clinical-stage pharmaceutical company discovering and developing therapies targeting mitochondrial disease. Founded by Professor Jan Smeitink, a world-leader in mitochondrial medicine, we are advancing our proprietary science through a wholly-owned clinical and preclinical small molecule pipeline of potential medicines.   

Our priority is to rapidly develop our pipeline to deliver transformative medicines for patients living with mitochondrial disease. Our in-house scientists are driving innovative research projects and  building a portfolio of promising compounds. We have active discovery programmes underway developing new therapies, biomarkers, diagnostic applications and new read-out technologies in the field of mitochondrial diseases.

Our lead pipeline asset, sonlicromanol , is a potential Phase 3 ready first-in-class oral small molecule in clinical development to treat a range of primary mitochondrial diseases. It has been granted Orphan Drug Designation for  for all inherited mitochondrial respiratory chain/oxidative phosphorylation disorders in the US en EU.  

We work in collaboration with patient organisations internationally as well as a global clinical and academic network to accelerate the discovery and development of our potential medicines for patients with mitochondrial diseases

KHONDRION

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