NanoFuse Biologics LLC (a NANISX LLC company and KIC Ventures portfolio member) develops advanced solutions for bone regeneration. Our flagship product, NanoFuse® DBM, is the first FDA‑approved combination of synthetic bioactive ceramic 45S5 bioglass and demineralized bone matrix (DBM) designed to promote fusion and accelerate healing. Upon contact with body fluids, NanoFuse rapidly forms a 3D ultra‑porous calcium hydroxyapatite layer within 24 hours, creating a strong bond with adjacent bone, triggering osteoblast differentiation, and enhancing osteogenesis. In vitro data also show ionic release and pH changes from the bioactive glass that discourage microbial growth, providing an additional antimicrobial benefit. Guided by LESS™ Exposure Spine Surgery principles and the REP (Restore Function, Early Intervention, Preserve Anatomy) methodology, NanoFuse Biologics is a trusted, clinically proven, patented bone void filler for fusion and regeneration.

NanoFUSE Biologics

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