PhoenixBio established its proprietary chimeric mouse model, the PXB-mouse®, with a highly humanized liver through years of research and development. With the addition of fresh, isolated human hepatocytes, PXB-cells®, the applications of our products and study services are as wide-ranging as our clients’ research goals. 

The PXB-mouse animal background (cDNA-uPA/SCID) makes for a robust, consistent model that maintains up to 95% stable human hepatocyte engraftment. The reconstituted humanized liver features structural and biological characteristics commonly observed in normal human livers. 

The model has proven to be a world-wide gold standard for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) research, but usage is expanding in the fields of:

.        Drug Metabolism and Pharmacokinetics,
·        Human Specific Hepatotoxicity,
·        Oligonucleotide and Gene-based Therapeutics,
·        HBV & HBV/HDV,
·        NASH/NAFLD,
·        Other human liver-related research fields.

PXB-cells® are approximately 95% pure human hepatocytes freshly isolated from the PXB-mouse®. They feature long-term stability of up to 40 days, and allow for consistent supply from the same donor. One unique feature of PXB-cells® and PXB-mice is the ability to directly compare in vitro and in vitro data from the same human donor.
 
With over 300 scientific publications to its credit, the PXB-mouse is the world’s most widely used chimeric mouse model with a humanized liver. A high replacement index, lifespan of up to 2 years, and no secondary drug to maintain mouse liver injury means that your data can translate better to humans than ever before.

Please visit our website at https://www.phoenixbio.com/ to learn more about our model and inquire about our offered products and services. 


Biotechnology

Life Sciences

Pharmaceutical

Therapeutics

PhoenixBio

PhoenixBio's headquarters in Higashi-Hiroshima City, Japan

This department focuses on identifying and pursuing growth opportunities through strategic partnerships and market expansion.

Business Development

This department focuses on strategic planning and execution to drive business development initiatives related to research.

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Research Planning & Business Development