Terraferma's high-yielding fermentation platform bridges the gap between computational protein design and commercial production, combining AI-guided strain engineering with ultra-high-throughput genetic screens to improve recombinant protein titers. 

Computationally designed proteins often fail to express at commercially viable levels – a critical barrier to commercialization across therapeutic, industrial, and food applications. Systems capable of multi-gram-per-liter titers are required to solve this. Our AI-guided optimization platform has led to >100x improvements over off-the-shelf strains, achieving double digit titers across a range of protein types.

Developed by MIT- and Harvard-trained scientists with expertise in synthetic biology, high-throughput screening, and machine learning (publications in Nature and Molecular Cell). Terraferma generates and maintains one of the largest proprietary datasets linking yeast genotype to expression phenotype.

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