Tinker is a pre-clinical stage biopharmaceutical company. Founded by pioneering executives and scientists in oligonucleotide and neurodegenerative disease therapeutics, Tinker is advancing next-generation engineering of multimeric siRNAs and ASOs. 

Tinker's proprietary FORGE platform, leveraging cross-species translational screening, unlocks unparalleled design and optimization of multimeric constructs with tunable linkers in dimer, trimer, and tetramer configurations. Monomers are individually modified with a novel conjugate and proprietary chemical modification patterns for superior CNS distribution and durable knockdown which outperforms current best-in-class technology for siRNA-mediated knockdown in all brain regions. This delivers a multi-targeting configuration through a single chemical entity for simultaneous silencing, up-regulation, or precise combinatorial knockdown with finely tuned polypharmacology aligned with disease-specific synergistic gene networks for combinatorial efficacy.

Tinker Therapeutics

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Tinker Therapeutics

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