Ti sento means “I hear you" in Italian.

At Tisento Therapeutics, we believe that meaningful innovation requires understanding the problem, and that starts with listening. First and foremost, we listen to those impacted by debilitating diseases to understand the daily challenges they face. We also listen to healthcare providers, patient advocates, regulatory agencies, and scientific data. All these inputs inform our thinking and shape how we conduct our research, design our trials, and evolve our company. We are on a mission to deliver medicines that address what matters most.

Our lead candidate is zagociguat (formerly CY6463), a Phase 2, first-in-class, brain-penetrant sGC stimulator, which is advancing in MELAS and other genetic mitochondrial diseases. Zagociguat is ideally suited to treat mitochondrial diseases with both CNS and peripheral symptoms, such as cognitive impairment, fatigue, and muscle weakness.

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Tisento Therapeutics

Peter Hecht

G. Todd Milne

This department oversees the management and execution of clinical research and drug development processes.

Pharmaceutical Operations

This department oversees the planning, execution, and completion of projects and initiatives, ensuring alignment with organizational goals.

Program Management

This department oversees the strategic direction and overall management of the organization.

Tisento Therapeutics

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Teams

Pharmaceutical Operations

Program Management

Executive Leadership

Offices

Tisento Therapeutics

Org chart

Teams

Pharmaceutical Operations

Program Management

Executive Leadership

Offices

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