Jagdeep Nanchahal

Professor Nanchahal is a surgeon scientist at the University of Oxford, focused on defining the molecular mechanisms of common diseases such as fibrosis and translating his findings through to early phase clinical trials.

His surgical background has allowed him to bring a unique insight to common, yet relatively neglected diseases.

Many of his findings stem from investigations in primary human tissues, rather than relying on animal models that often fail to recreate human clinical conditions.

He has pioneered the treatment of fibrosis of the hand (Dupuytren’s disease), which unlike fibrosis in major human tissues can be diagnosed early and samples easily obtained to discover new pathways of importance.

In 2013 his group identified TNF⍺ as a target for Dupuytren’s disease, leading to a phase 2a clinical trial to determine the effective dose and preparation of anti-TNF.

He is now leading the Phase 2b/3 trial funded by the Wellcome Trust and UK Department of Health.

Professor Nanchahal is a member of the Royal College of Plastic Surgeons.