Acelot is treating functional protein misfolding diseases where the appropriate therapeutic mechanism is a restoration of the normal protein homeostasis. Functional misfolded proteins are found in various diseases such as ALS, FTD, Parkinson’s, diabetes and cancer. Acelot’s platform combines generative AI, molecular dynamics simulations and proprietary assays to discover small molecules that restore the homeostasis of misfolded proteins in various diseases.  We have a pipeline of hit-to-lead discovery compounds across multiple indications, along with an IND-ready candidate for ALS.  Our platform was invented by UCSB Computer Science Professor Dr. Ambuj Singh. 

Acelot’s first development candidate, ACE-2223, is a first-in-class orally bioavailable small molecule that will undergo IND-enabling studies in 2024. ACE-2223 disrupts the misfolded forms of TDP43 and restores functional TDP43. It acts upon the misfolded conformations of TDP43 found across various patient populations, including ALS, FTD and Alzheimer’s.  ACE-2223 has excellent brain penetrance and ADME properties. Acelot also has a robust discovery pipeline.

Biotechnology

Life Sciences

Therapeutics

Acelot

The South San Francisco office likely focuses on research and program management in a biotech or pharmaceutical context.

South San Francisco

Acelot's headquarters in Palo Alto, CA, United States

Katie Planey

Lewis Whitehead

This department focuses on analyzing complex data to derive insights and inform decision-making through scientific methods.

Data Science Division

This department focuses on delivering expert software advice and developing training programs to enhance skills and knowledge.

Consulting and Training

This department focuses on the development of drugs and therapeutic methodologies within the pharmaceutical sector.

Pharmaceutical Development

This department oversees the planning, execution, and delivery of programs and projects to meet organizational goals.

Program Management

This department focuses on innovating and developing new products and technologies.

Research and Development

This department conducts studies and analyses to generate knowledge and insights.

Acelot

Org chart

Teams

Data Science Division

Consulting and Training

Pharmaceutical Development

Program Management

Research and Development

Research Department

Offices

Acelot

Org chart

Teams

Data Science Division

Consulting and Training

Pharmaceutical Development

Program Management

Research and Development

Research Department

Offices

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