Leslie Nangle

Leslie Nangle, Ph.D., has served as our Vice President, Research since January 2021. Dr. Nangle has served in scientific research roles at aTyr since joining the company in 2007, including most recently as Sr. Director and Head of Research. Dr. Nangle has over 20 years of experience in research dedicated to extracellular tRNA synthetases. Throughout her tenure at aTyr, she has co-developed and implemented the company’s discovery platform to generate an intellectual property estate of over 300 potential therapeutically relevant proteins and has overseen research leading to the discovery of a splice variant of histidyl-tRNA synthetase that has been shown to modulate the immune system, providing the basis of aTyr’s lead program, ATYR1923. Prior to joining aTyr, Dr. Nangle received a Ph.D. in Macromolecular Cellular Structure and Chemistry from The Scripps Research Institute in La Jolla, CA, studying the emerging linkage between mutations in tRNA synthetases and inherited neuropathies under the mentorship of Dr. Paul Schimmel, who co-founded aTyr in 2005. Dr. Nangle received a bachelor of science in biology from the University of California at Santa Barbara. She is co-author or co-inventor of over 75 publications and issued or pending U.S. patents.