Neal Rosen MD, PhD is a member of the Program in Molecular Pharmacology and the Department of Medicine at Memorial Sloan-Kettering Cancer Center where he also is the incumbent of the Enid Haupt Chair in Medical Oncology. He has pioneered the ideas that oncogene-induced negative feedback plays important roles in determining mechanisms of tumorigenesis and progression and that its relief causes adaptive resistance to targeted therapies. He has also played important roles in developing therapeutic strategies for inhibition of RAS/RAF/MEK or PI3K/mTOR signaling.