DICE Therapeutics
Prior to becoming Chairman of the Board at DICE Therapeutics in late 2015, Dr. Scheller had joined 23andMe in January 2015 as Chief Scientific Officer and Head of Therapeutic Development. There, he is responsible for translating genetic information into new therapies.
Hired in 2001 as Senior Vice President of Research and member of the Genentech Executive Committee, from 2009 through 2014, he was Executive Vice President and Head of Genentech Research and Early Development, and a member of the Roche Executive Committee. Dr. Scheller received his Bachelor of Science in biochemistry in 1975 from the University of Wisconsin–Madison and his doctorate in chemistry in 1980 from Caltech. After postdoctoral fellowships at Caltech and Columbia, Dr. Scheller joined the Stanford faculty from 1982 until 2001. An investigator with the Howard Hughes Medical Institute from 1994 to 2001, Dr. Scheller has been an adjunct professor at UC San Francisco since 2004. In 2014, he was named a trustee of Caltech.
Dr. Scheller’s research elucidating molecular mechanisms governing neurotransmitter release earned him the 2013 Albert Lasker Basic Medical Research Award, the 2010 Kavli Prize in Neuroscience, and the 1997 US National Academy of Sciences Award in Molecular Biology. He is a Fellow of the American Academy of Arts and Sciences, and a member of the National Academy of Sciences and the National Academy of Medicine.
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DICE Therapeutics
At DICE Therapeutics, we design and develop innovative therapies in immunology for patients with debilitating disease. Seeking to create a future where convenient oral medicines with biologic-like efficacy are available to patients with serious medical conditions, we are developing oral alternatives to medicines currently limited to injectable forms. We believe that such pills will be widely appreciated by patients and doctors alike, as they provide a lower bar to entry than biologics, and as oral medicines can easily be co-formulated with other efficacious drugs. The combination of our core technology with additional, unique biophysical insights has enabled DICE to target protein-protein interactions with small molecules. In doing so, DICE has cracked open a previously intractable set of clinically validated therapeutic targets, including Interleukin-17 (IL-17). Our lead program – an orally bioavailable IL-17 antagonist for the treatment of psoriasis – is currently progressing through IND-enabling studies. In parallel, we continue to advance both partnered and internal pipeline drug discovery programs, providing a robust pre-clinical pipeline.