Sacha trained in medicine at Nottingham University and in medical oncology at The Christie NHS Foundation Trust. He gained his PhD in medical oncology at The University of Manchester in 2006, studying the role of prolactin in breast cancer stem cell regulation. He was appointed Senior Lecturer in Breast Oncology at The University of Manchester in October 2010 and works closely with the basic scientists in the Manchester Breast Centre, focusing on the translation of novel approaches to targeting normal and cancer stem cells into breast cancer prevention and treatment respectively.