Sean O’Malley

Sean has nearly 30 years of experience in synthetic organic and medicinal chemistry, rational drug design, and molecular modeling. He has supervised high-throughput docking, screening, analytical, biochemical, and hit-to-lead and lead optimization medicinal chemistry activities with a team of scientists at Hawaii Biotech, as a program supervisor in a matrix management context. In addition, he has overseen external CRO activities including: ADME assays, PK and tox studies; animal efficacy studies, model development, and optimization and implementation of scale-up process chemistry methods for bulk syntheses of key investigational compounds. He has served as Principal Investigator on multiple NIAID grants and DoD contracts. Current and past projects include work in biodefense antitoxin therapeutics, antibody-directed enzyme-activated anticancer and antifungal prodrug design, and immunoassays. He holds a BA in Chemistry from the University of Virginia and a Ph.D. in Organic Chemistry from the University of Texas at Austin.