Dr. Isaac Samuel Kohane is the Chair of the Department of Biomedical Informatics at Harvard Medical School. He applies computational techniques, whole-genome analysis, and functional genomics to study human diseases through the developmental lens, particularly through the use of animal model systems. Kohane has led the use of whole healthcare systems, notably in the i2b2 project, as “living laboratories” to drive discovery research and comparative effectiveness with software and methods adopted in over 84 academic health centers internationally.