Incendia Therapeutics is discovering and developing novel anti-cancer medicines that are designed to reprogram the tumor microenvironment. Many cancers create immune exclusion barriers that prevent the immune system from attacking tumors. The Parthenon approach to overcoming these barriers is to modulate the interplay among cancer cells, stromal cells, and immune cells.  
  
Our lead program, PRTH-101, is a first-in-class humanized monoclonal antibody that blocks the interaction of Discoidin Domain Receptor 1 (DDR1) with collagen, thereby “punching holes” in the extracellular matrix barrier created by the tumor. With the extracellular matrix barrier breached, immune cells are able to infiltrate and attack the tumor.  PRTH-101 is poised to enter Phase 1 clinical trials.  
 
PRTH-101 is followed by a pipeline of preclinical projects targeting orthogonal components of the tumor microenvironment that promote immune exclusion.  

Incendia combines its drug discovery and development efforts with a precision oncology approach to get the right medicines to the right patients. We use proprietary AI technology to digitally deconstruct the TME and develop unique insights to enable biomarker-driven patient selection strategies designed to guide clinical applications.  

Biotechnology

Health Care

Life Sciences

Pharmaceutical

Incendia Therapeutics

Wendye Robbins

Vito Quaranta

Peter Cincotta

Irena Webster

Joseph Paul Eder

Thomas Schürpf

Susan G. Macdonald

Jeff Janotka

Christopher O’donnell

Mace Rothenberg

The Research and Development team at Incendia Therapeutics is focused on discovering and developing novel anti-cancer therapies that modulate the tumor microenvironment to overcome immune exclusion barriers. They lead the development of groundbreaking programs, such as the PRTH-101 monoclonal antibody, and manage the pipeline of preclinical projects targeting various aspects of the tumor microenvironment. This team integrates proprietary AI technology and precision oncology to enable biomarker-driven patient selection, ensuring that the right medicines reach the right patients.

Research and Development

Leadership Team

Scientific and Research Team

Research and Development

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Leadership Team

Scientific and Research Team