Dr. McManus served as the inaugural Scientific Director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research and has an active clinical investigative program focused on enteroviral heart disease, transplant vascular disease, and novel blood biomarkers of heart, lung, and kidney failure and transplantation. He works in a cross-disciplinary setting focused on translational research questions enabled by computational sciences and including biomarker discovery and validation. Dr. McManus has co-authored over 350 full length publications, has been recognized by numerous awards, serves on many editorial boards and advisory committees, is committed to training and mentoring trainees, and has convened many public and private sector partnerships in research.