Lennart Mucke

Lennart Mucke’s lab focuses on how major neurological and psychiatric conditions cause cognitive deficits, behavioral abnormalities, and other disabling symptoms, with an emphasis on dementias, epilepsy, and autism. The group uses mouse models and brain cell cultures to study disease-causing factors and pathways at molecular, cellular, network, and behavioral levels. Such models are also used to identify and validate novel entry points for therapeutic interventions. The relevance of the models is assessed through comparative studies of human patients and postmortem tissues. The most informative models have been used to identify novel strategies to counteract the development of brain dysfunctions and neurological decline.