Neal Rosen

Dr. Neal Rosen, Enid A. Haupt Chair in Medical Oncology, is a member of both the Department of Medicine and the Program in Molecular Pharmacology and Chemistry at the Memorial Sloan-Kettering Cancer Center. He is also a Professor of Pharmacology, Cell Biology and Medicine at the Cornell University Medical School. He completed a residency in Internal Medicine at the Brigham and Women’s Hospital and post-doctoral training and a fellowship in Medical Oncology at the National Cancer Institute, and was on the senior staff of the Medicine Branch at the NCI prior to joining the faculty of Memorial Sloan-Kettering Cancer Center.

Dr. Rosen’s major interests include the identification and study of the key molecular events responsible for the dysregulation of growth signaling in carcinomas and the use of this information for the development of effective therapeutic strategies. He has played an important role in the development of multiple inhibitors of receptor mediated signal transduction and has generated the concept that oncoprotein induced feedback inhibition of the signaling network is a major determinant of the transformed phenotype and the response of the tumor to targeted therapy. Recent work includes the elucidation of the biochemical and biologic mechanisms of action of RAF inhibitors, the mechanisms underlying resistance to these compounds, and studies on the role of ERK-dependent feedback in tumors with RAF or RAS mutation. His work has led to multiple clinical trials in the United States and internationally.

Dr. Rosen received his undergraduate degree in Chemistry from Columbia College and an Member – Scientific Advisory Board PhD in Molecular Biology from the Albert Einstein College of Medicine, New York.