Harold S. Bernstein, MD PhD

President of Research & Development | Chief Medical Officer at Maze Therapeutics

Harold S. Bernstein, MD PhD has a diverse work experience in the field of research and development, clinical development, and academia. Harold S. is currently serving as the President of Research & Development and Chief Medical Officer at Maze Therapeutics since 2022. Previously, they held various positions at renowned companies such as BioMarin Pharmaceutical Inc., where they served as the Chief Medical Officer, Head of Global Clinical Development, and Senior Vice President of Worldwide R&D from 2021 to 2022. Prior to that, they worked at Vertex Pharmaceuticals as the Head of Translational Medicine and Vice President of Global Medicines Development from 2017 to 2021. Harold S. also had a significant role at Merck, where they served as the Head of Cardiometabolic Diseases and Executive Director of Early Clinical Development from 2013 to 2017.

Alongside their industry experience, Dr. Bernstein has a strong academic background. Harold S. worked as an Adjunct Professor of Pediatrics (Cardiology) and Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai since 2013. Before that, they held the position of a Professor of Pediatrics (Cardiology) at the University of California, San Francisco from 1997 to 2013.

Additionally, Dr. Bernstein has contributed to the field of regenerative medicine as an Author and Guest Editor at Springer Nature, specifically in the area of Tissue Engineering in Regenerative Medicine from 2010 to 2011. This demonstrates their involvement in scholarly pursuits alongside their professional roles.

Harold S. Bernstein, MD PhD, holds a diverse educational background. Harold S. earned their AB degree in Biological Sciences from Harvard University. Following this, they pursued their medical training at Mount Sinai School of Medicine of New York University, where they obtained an MD degree in Medicine. As part of their medical education, Harold also pursued a MPhil/PhD degree in Human Genetics.

During their education, Harold gained further specialized knowledge and experience through various fellowships and training programs. Harold S. completed a residency and clinical fellowship in Pediatrics/Cardiology at the University of California, San Francisco. Additionally, they served as a Postdoctoral Fellow in Cardiovascular Biology at the Cardiovascular Research Institute/University of California San Francisco.

In addition to their academic achievements, Harold has obtained certifications in various areas related to leadership and business. Harold S. completed the "Leading in the Matrix" program at Korn Ferry in 2020, and the "Pharmaceutical Industry Business Simulator" program at BTS in 2018. Furthermore, they have completed the "Build the Best Teams & Talent" program at Harvard Business School Executive Education and the "Business Acumen for Drug Discovery" program at iQue Group in 2016.


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  • President of Research & Development | Chief Medical Officer

    October, 2022 - present

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