John Castle

Dr. John Castle is Chief Data Scientist at Monte Rosa Therapeutics. Dr. Castle has deep expertise in biomarkers and therapy development using computational immunology, bioinformatics, biotechnology, and genomics.

Having built translational bioinformatics and genomics units focused on immunotherapies, Dr. Castle pioneered computational approaches to neoantigen identification for anti-tumor immunity. His bioinformatics and ‘omics approach revolutionized neoantigen vaccine platforms, TCR target identification and I-O response biomarkers.

Prior to joining Monte Rosa, he was Associate Vice President for Translational Sciences at Agenus, served as associate director at Rosetta Inpharmatics/Merck & Co. and subsequently co-directed the Biomarker Development Center of Translational Oncology at the University of Mainz, Germany. Dr. Castle built the bioinformatics and genomics department at BioNTech AG. Dr. Castle studied physics at Rice University in Houston and at the University of Göttingen in Germany, was a Fulbright Scholar at the Australian National University in Canberra and received his Ph.D. in geophysics from the University of Washington in Seattle.