Mcebisi is a former Deputy Finance Minister of the Government of South Africa who served from 2014 to 2017. Before his appointment to national government, he played a key leadership role in the Eastern Cape. He served as a provincial minister of Finance as well as Economic Development, Environmental Affairs and Tourism in the province. He also served as Chief Executive Officer of the Eastern Cape Development Corporation as well as Chief Executive Officer of the Centre for Investment and Marketing in the Eastern Cape, developing the investment promotion agenda for the province.