Rémi SERRANO

Imagine having access to the closest in vivo model possible at the earliest stage of the development of your new anti-cancer drug? This new approach enables confident decision-making during safety and efficacy tests of your synthetic molecules or your natural extracts in development. Our patented technology, based on synthetic pearls, allows very rapid analysis of molecules potentially identified as promising, and to validate them before a clinical trial phase, in complete operational safety. Keywords: Drug Discovery Service - HCS (High content screening) - Cancer drugs – IBD (Inflammatory Bowel Diseases) - Prostate cancer - Bladder cancer - Gastrointestinal cancer - Breast cancer - Animal free anticancer tests – Organoid - 3D cell culture - 2D cell culture – Spheroid - Target Validation - Lead Optimization - Translational research - Target Identification Pearl BioSystem is a pioneering company that has developed an original and very effective 3D culture test for synthetic and/or natural compound tests, as well as validation tests. Over the past 10 years, Pearl BioSystem scientists have developed a rapid and accurate method for screening chemical libraries in liquid pearls, an animal-free model equivalent to xenograft experiments in nude mice. Thanks to its validated technology, Pearl BioSystem (PBioS) can develop a tailor-made test on a weekly basis to evaluate and/or compare specific candidate molecules with precision, reliability, and efficiency. Our pearls can be compared to mini-incubators of cancerous and metastatic cells offering: • Reproducibility • Translation into in vivo 2D models • Oxygen gradients • Low oxygen content avoiding oxidation of the drugs tested • Nutrient gradients • Size measurement in microscopy • Volume measurement in microscopy • Visualization of a possible metastatic loophole • Kinetics in 3D cultures • EC50 without animals Our key advantages • Reliability • Precision• Reproducibility • Cost efficiency • Rapidity