Spring 2025 Co-op: Mrna & LNP Process Development

Co-Op Assignment Overview 

Prime Medicine is seeking a co-op for the Spring 2025 semester to work in a cross-functional LNP formulation and process development team. The candidate will work with formulation scientists, process development engineers, and chemical engineers to optimize mRNA and LNP formulation and processes related to the manufacture of mRNA and LNPs. The candidate will gain hands-on experience with various LNP formulation techniques and processes, analytical and biophysical characterization, and play a critical role in solving challenging problems associated with LNP formulation and process development.     

We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being. 

Primary Responsibilities: 

• Collaborate with the mRNA and LNP formulation and process development team, and cross-functional teams to execute experiments supporting Prime Medicine goals 
• Execute experiments to optimize and understand the robustness of LNP formulations and related processes 
• Perform analytical testing for assessing LNP formulations and payload quality as it relates to critical process parameters
• Effectively communicate results to internal and external meetings, and present the final summary to the team
• Document and manage all experimental planning and progress in electronic lab notebook in an organized manner, providing statistical analysis and troubleshooting where appropriate.
• Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies 

Qualifications: 

• Enrolled in B.S./M.S. in Chemical Engineering, Chemistry, Bioengineering or Biochemistry  
• Prior experience with mRNA and LNP formulations and processes of making LNPs, and wet lab is preferred. 
• Prior Co-Op experience(s) is preferred.  
• Knowledge of tangential flow filtration, and characterization techniques (DLS, UV-Vis, HPLC)  
• Familiarity with DOE is a plus
• Excellent written and verbal communication skills.
• Curious, ability to work independently or collaboratively as needed
• Self-motivated, detail-oriented with strong critical thinking skills and excel at identifying and solving problems. 

What We Offer:

• A cutting-edge team open to mentorship and networking.
• Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
• Participation in regular seminars with industry experts.
• Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.