Yi-Tao Yu

Yi-Tao is a Dean’s Professor at the Center for RNA Biology and in the Department of Biochemistry and Biophysics at the University of Rochester Medical Center. He has been working on pre-mRNA splicing and RNA modification for more than 20 years. One of the projects currently being carried out in his lab focuses on nonsense suppression. Specifically, his lab is developing a novel approach, namely targeted RNA pseudouridylation, to precisely modify the pre-mature translation termination codons (PTCs, resulting from nonsense mutations) present in mRNAs, thus suppressing nonsense-mediated mRNA decay (NMD) and promoting PTC read-through to restore full-length proteins. His work has made significant contributions to this field of research.