He is considered a leading expert on protein purification and characterization, RNA polymerases and transcription machinery, regulation of gene expression, and use of monoclonal antibodies in protein biochemistry. He was the founder and director of the UW-Madison Biotechnology Center (1984-96) and is a leading figure in the Wisconsin biotechnology business community. He earned his B.S. in Chemistry from the California Institute of Technology and his Ph.D. in Biochemistry and Molecular Biology from Harvard University under James D Watson in 1969.
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