Stephen Lyle

Dr. Lyle is a physician-scientist with expertise in the pathologic evaluation of tissues and biologic samples. In addition to his seminal work characterizing the molecular and biologic properties of adult stem cells, he has made significant contributions in translational cancer research and the commercialization of new diagnostics.

Dr. Lyle is the Director of KEW Group’s Molecular Diagnostics Lab and is the former Lab Director of Predictive Biosciences, and former Medical Director of Catalyst Oncology, Inc. He has served as a consultant for a number of biotech companies including Pavonis/Beauty Medicines, Switch Biotech AG, Andorra, Inc./Living Proof, Dyax Corp., Diagnocure, Inc., Arresto Biosciences, Merrimack Pharmaceuticals and Bioserve.

Dr. Lyle holds an appointment as Associate Professor of Cancer Biology and Pathology, UMass Medical School and is the Co-Director of the UMass Cancer Center Tissue Bank. He has held NIH and private foundation grants to study adult stem cell biology, cancer stem cells and skin biology. He has received a multiple awards, grants and fellowships from The National Institutes of Health, William Keck Foundation, The Ellison Foundation, Society of Investigative Dermatology, Dermatology Foundation, Burroughs Wellcome Trust, and The March of Dimes. He is a member of The American Association for Cancer Research, The Society of Investigative Dermatology and is a Fellow of the College of American Pathologists. He is an author on over 75 research publications, book chapters and reviews.

Prior to his clinical fellowship training in the Harvard Combined Dermatopathology Program, he was a resident and surgical pathology fellow at the Hospital of the University of Pennsylvania, where he received the prestigious HT Enterline Fellowship Award. While at the University of Pennsylvania, he also completed a research post-doctoral fellowship in the lab of George Cotsarelis, M.D. in the Department of Dermatology. During this time Dr. Lyle made the breakthrough discovery of the location and characteristics of adult epithelial stem cells in human skin that launched his research career.

Dr. Lyle is a graduate of The Pritzker School of Medicine/University of Chicago where he completed his M.D. and Ph.D. in Biochemistry and Molecular Biology. He also graduated with honors from the University of Chicago in the combined B.A. / M.S. program in Biochemistry.