Dr. Lodish received his A.B. degree summa cum laude in chemistry and mathematics from Kenyon College in 1962 and his Ph.D. degree in genetics from the Rockefeller University in 1966. Following two years of postdoctoral research at the MRC Laboratory of Molecular Biology with Drs. Sydney Brenner and Francis Crick, he joined the faculty of the MIT Department of Biology. He was promoted to professor in 1976, and in 1983 was appointed founding member of the Whitehead Institute for Biomedical Research. In 1999, he also became Professor of Biological Engineering in the new MIT Department of Biological Engineering.
He was elected a fellow of the American Association for the Advancement of Science in 1986, a member of the National Academy of Sciences in 1987, and a fellow of the American Academy of Arts and Sciences in 1999. He is a member of the Board of Trustees of Boston Children's Hospital, where from 2007 to 2019 he chaired the Board Research Committee. He is also the lead author of the textbook Molecular Cell Biology; the ninth edition was published in late 2020. During the 2004 calendar year, he served as President of the American Society for Cell Biology. Dr. Lodish was a founder and scientific advisory board member of several biotech companies including Genzyme Inc., Millennium Pharmaceuticals, and Rubius Therapeutics. From 2008 to 2015, he served as the founding chair of the Scientific Advisory Board of the Massachusetts Life Sciences Center, the group charged with oversight of the state's 10-year, $1 billion investment in the life sciences.
Over 200 MD, PhD, and MD/PhD students and fellows have trained in his laboratory; two of his trainees have received the Nobel Prize and eight have been elected to the U.S. National Academy of Sciences or the National Academy of Medicine.