Geoff Shapiro

Dr Shapiro received his PhD in 1987 and his MD in 1988 from Cornell University, followed by postgraduate training in internal medicine at Beth Israel Hospital, Boston, where he served as chief medical resident. He completed a fellowship in medical oncology at Dana-Farber Cancer Institute, Boston, during which he investigated the role of cell-cycle-related proteins in lung cancer.

He joined the Dana-Farber faculty in 1994. Dr Shapiro is Leader of the Early Drug Development Center at the Dana-Farber, Clinical Director of the Dana-Farber Center for DNA Damage and Repair, and co-Leader of the Developmental Therapeutics Program at the Dana-Farber/Harvard Cancer Center (DF/HCC). He is the Principal Investigator on the NCI-CTEP grant supporting the activities of the DF/HCC in the Experimental Therapeutics Clinical Trials Network (ETCTN).

Dr Shapiro directs both basic and translational research on cyclin-dependent kinase inhibitors, as well as inhibitors of DNA repair. In addition, he also leads multiple early phase clinical studies of inhibitors of signal transduction, cell cycle and DNA repair, used alone, in targeted combinations or in combination with immune checkpoint blockade in patients with advanced solid tumours.