RNA Biophysics Scientist

Atomic AI, Inc. is a well-funded, early-stage biotech company transforming the rational design of molecules and medicines through the cutting-edge fusion of artificial intelligence and structural biology. Atomic’s unique R&D platform, based on research featured on the cover of Science (doi.org/10.1126/science.abe5650), provides new strategies to treat or cure previously undruggable diseases by targeting RNA structure. We are an interdisciplinary team working across computational and experimental biology and believe that our strongest asset is our people.

This position reports to the incoming RNA Biosciences Lead.

Responsibilities:

• Work with company leadership to advance our strategy for targeting RNA with small molecules and RNA degraders.
• Develop RNA screening strategy, establish screening platform and relevant technologies internally and/or in collaboration with external partners including but not limited to ASMS, Microarray, SPR, ITC, and/or other relevant biophysical methods.  In addition, evaluate any new methods and implement them as necessary.
• Enable RNA-directed small molecule drug discovery efforts.  Establish validated processes for small molecule hit ID, validation, and lead optimization for RNA targets.  Deliver on program requirements in a timely manner.
• Collaborate with the drug discovery, ML data and ML teams to build an integrated workflow to support RNA biology programs.
• Provide scientific leadership and perform day-to-day lab activities.
• Work in close collaboration with external partners as appropriate to build technical capabilities.
• Communicate with leadership regularly to provide regular updates on the projects/programs to enable efficient decision-making.  

Experience:

• PhD in biological sciences with at least 5-year experience in RNA-targeted small molecule discovery. 
• Proven hands-on experience in working with RNA targets and related screening technologies including but not limited to ASMS, ALIS, Microarray, SPR, ITC.
• Ability to evaluate newer methods as appropriate and implement novel approaches to screen RNA as needed.
• Ability to independently drive, manage, execute, and deliver results on key programs under tight timelines.
• Ability to work in a collaborative environment to enable integration of state-of-the-art technology platform with RNA biology to accelerate the program pipeline.
• Ability to manage workflow internally and working through third party laboratories. 

Salary Range: $145,000/year to $160,000/year + equity + benefits