Sarmistha Banerjee

Sarmistha Banerjee is a Senior Scientist at Cabaletta Bio. Prior to this, they were a Senior Research Investigator at the University of Pennsylvania from 2019 to 2021. During this time, they developed Universal canine CAR T cell through CRISPR/Cas9 genetic manipulation of TCR, \u03b2-2 microglobulin (B2M) to provides an alternative and potentially improves current chimeric antigen receptor (CAR) T-cell therapy. Sarmistha also determined the mechanism and the breadth of hematopoietic lineage plasticity of YY1-null pro-B cells. Before this, they were a Research Associate and Senior Postdoctoral Fellow at the University of Pennsylvania from 2010 to 2019. During this time, they conducted in vivo experiments with large sets of rat including breeding, colony maintenance, treatment, starting from neonatal to adult stage, sample collection, biochemical and molecular biology assay and data analysis. Sarmistha also executed in vitro experiments including isolation of primary hepatocyte, 3Dculture, drug treatment, to demonstrate changes in metabolic potential of adultCYP-450 activity by neonatal glutamate (MSG) exposure. Sarmistha identified epigenetic alteration (DNA hypermethylation of CYP2C11) caused by neonatal growth hormone ablation which irreversibly alters the adult expression of CYP2C11 in liver. Prior to this, they were a Postdoctoral Associate at Fox Chase Cancer Center from 2008 to 2010, where they established that monoclonal antibody to glucose transporter 1 (Glut-1) as a novel energy restrictor for breast cancer and conducted experiments using human mesothelioma cell lines to determined the role of conventional chemotherapy on excision repair gene (ERCC1). Sarmistha also held a Postdoctoral Research Fellow position at Moffitt Cancer Center from 2006 to 2008.

Sarmistha Banerjee obtained their Doctor of Philosophy (Ph.D.) in Oncology and Cancer Biology from Jadavpur University in 2006. Sarmistha also holds a Master of Science (M.Sc.) in Human Physiology from Vidyasagar University which they obtained in 2000. In addition, they have obtained several certifications including Learning Python from LinkedIn in 2020, CITI Research with data or laboratory specimens only in 2017, CITI Good Clinical practice in 2017, Advance SAS certification from SAS in 2016, Base SAS Certification from SAS in 2016, R Programming from Johns Hopkins University in 2015, Data Analysis and Statistical Inference from DataCamp in 2015, Design and Interpretation of Clinical Trials from Johns Hopkins University in 2015, edX Honor Code Certificate for Statistics and R for the Life Sciences from edX in 2015, and HIPAA Privacy and Security Education.