Luke Gilbert is an Assistant Professor in the Department of Urology, the Department of Cellular and Molecular Pharmacology, the Helen Diller Family Comprehensive Cancer Center and the Innovative Genomics Institute at the University of California, San Francisco. Gilbert was an early pioneer in repurposed CRISPR systems that are used to turn genes on (CRISPRa) and off (CRISPRi) by editing the epigenome. More recently, the Gilbert lab has developed new strategies for editing heritable epigenetic memories (CRISPRoff/on) and for systematically mapping human genetic interactions at very large scales or at single cell resolution. The Gilbert lab is focused on using CRISPR to tackle big problems in human biology. Gilbert is the Goldberg-Benioff Endowed Professor in Prostate Cancer Translational Biology and has been awarded a NIH Director’s New Innovator Award, a Pew-Stewart scholar for cancer research award, the AAAS- Martin and Rose Wachtel Cancer research award, a Gabrielle’s Angel Foundation for Cancer Research award and an NIH Pathway to Independence Award. Gilbert holds a Ph.D. in biology from the Massachusetts Institute of Technology and completed his postdoctoral training at the University of California, San Francisco.