Timothy A. Chan

Dr. Chan is a cancer geneticist and physician scientist with an interest in immunogenomics and immunotherapy. He is currently Vice Chair of the Department of Radiation Oncology and the Frederick Adler Chair at the Memorial Sloan Kettering Cancer Center (MSKCC). He is a member of the Human Oncology and Pathogenesis Program at MSKCC and director of the Division of Translational Oncology of the Department of Radiation Oncology. His main interests are utilizing cancer genomics, functional genomics, and statistical genetics to dissect the molecular determinants of tumor aggressiveness and response to cancer therapies. He led the team that first described mutational burden as a determinant of clinical benefit to immunotherapy and showed that mutational landscapes in lung cancer help determine response to immune checkpoint blockade. His lab is developing pioneering approaches to examine neo-antigen landscapes and the genomic foundations of response to cancer immunotherapy. He has contributed publications as first or senior author in journals such as Nature, Science, Cell, Nature Genetics, New England Journal of Medicine, and Science Translational Medicine.