Lisa Jones

Professor Lisa Jones has pioneered the field of in-cell and whole organism FPOP. At the University of Maryland, the Jones Lab is a structural proteomics group that uses biochemical, analytical, and biophysical approaches to study protein interactions important in biological processes. Their research focuses on the use of protein foot printing methods coupled with mass spectrometry to identify these interactions. A major focus of their lab is extending FPOP as an in cell method for monitoring proteins in their native cellular environment. This method would be especially useful for membrane proteins, the largest class of drug targets, which are challenging to study in vitro owing to the difficulty of purifying these proteins. The Jones lab has further expanded FPOP for in vivo analysis in C. elegans, an animal model for human disease.

Dr. Jones received her PhD at Georgia State University studying the affinity effectors of calcium binding proteins. She was a postdoctoral associate in the lab of Dr. Peter Prevelige at the University of Alabama-Birmingham where she used hydrogen deuterium exchange mass spectrometry to study protein interactions in virus capsids. Dr. Jones was a postdoctoral associate in the lab of Dr. Michael Gross at the Washington University in St. Louis where she expanded the use of the FPOP method for studying biologics.