Scot A. Wolfe

Dr. Scot Wolfe is a professor in the Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Chan Medical School. His research is focused on genome editing systems and protein-DNA interactions. His group is developing improved tools for targeted genome modification and gene regulation, with the goal of increasing their precision and effectiveness for therapeutic translation. This research has spanned developing a variety of improved CRISPR-based genome editing systems and new methods for engineering the DNA-binding specificity of zinc finger proteins. His team is focused on the therapeutic translation of their improved genome editing and gene regulation systems to specific disease applications, such as sickle cell disease, beta-thalassemia, various forms of muscular dystrophy, and Hermansky-Pudlak syndrome. He has published more than 65 research articles in peer-reviewed journals. He earned a Ph.D. at Harvard University and completed his postdoctoral research at the Massachusetts Institute of Technology.