Roberta Zappasodi

Roberta Zappasodi is an Assistant Professor of Hematology in Medicine in the Division of Hematology and Medical Oncology of the Department of Medicine at the Weill Cornell Medical College (New York, NY) and Visiting Investigator at Memorial Sloan Kettering (MSK, New York, NY). The overarching goal of her lab is to improve the understanding of the mechanisms underlying resistance to cancer immunotherapy. Specifically, her team is focused on studying immunosuppressive CD4+ T-cell subsets and the way these cells interact with B cells and impact B-cell function in response to immunotherapy with immune checkpoint blockade. In addition, she is investigating how tumor metabolism shapes the microenvironment to retain immunosuppressive and/or dysfunctional T cells.

Dr. Zappasodi’s work has contributed to identifying biomarkers of immune and anti-tumor activity with immediate clinical application and to improve the understanding of the mechanisms of action of immune checkpoint blockade therapy.