Principal Scientist Of Immunology

Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy. 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Principal Scientist of Immunology as part of the R&D team based in Piscataway, NJ. 

Role Overview

Legend Biotechnology is seeking a principal scientist to join our exploratory technology group and contribute to new technology/platform. The successful candidate should possess extensive knowledge and research experience in immunology, molecular biology and cell therapy, gene editing, in particular in vivo CART experience. The candidate should have comprehensive understanding of T/NK cell therapy, virus packaging, immune cell function assay. Experience with lentivirus gene therapy and in vivo CART is preferred. The candidate will be able to contribute to developing in vivo cell therapy platform through lentivirus vector design, ex vivo and in vitro function assay. 2-3 year biotech or pharmaceutical industry experience is preferred. The candidate needs to demonstrate the ability of delivering scientific results with integrity and meeting timeline, show the value of collaboration and teamwork, and provide strategy, expertise and guidance in a fast-paced environment.

Key Responsibilities  

• Develop cell therapy gene editing platform and optimize cell-based immunoassays, including virus packaging, immune cell isolation and expansion, multi-color flow cytometry, ELISA, cytotoxic assays.
• Independently design and execute experiments, document and interpret scientific results, present the data to peers
• Stay alert to industry development, good sense of new tech/platform in the field
• Deliver result and meet timeline, good communication and team work spirit
• Participate in lab support work.

Requirements

• PhD in Immunology / molecular biology/genetics, or master with extensive experience
• >3 years’ post-graduate experience in human immunology, virology or lentivector gene therapy, 2-3 years of industry experience is preferred, in vivo CART experience is a plus
• Molecular biology, vector design, gene-editing, CART

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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.