Sangram Sisodia

Dr. Sangram Sisodia is currently The Thomas Reynolds Sr. Family Professor of Neuroscience and Director of the Center for Molecular Neurobiology in the Department of Neurobiology at The University of Chicago. He has made several notable contributions in understanding the cellular and molecular biology of the amyloid precursor protein (APP) and presenilins (PS1 and PS2), polypeptides that are mutated in pedigrees with familial Alzheimer's Disease (FAD). The generation and characterization of mice expressing FAD-linked variants of PS1 and APP that exhibit amyloid plaques in the brain and that develop memory deficits has been invaluable for understanding neuronal vulnerability, and the impact of environmental enrichment and exercise in modulating the deposition of amyloid in plaques and adult neurogenesis. Dr. Sisodia has received several awards, including the Potemkin Prize for Alzheimer's Disease Research from the American Academy of Neurology and the Metropolitan Life Foundation Award for Medical Research.