Jason J. Luke

Scientific Advisor at Xilio Therapeutics

Jason J. Luke, M.D. is director of the UPMC Hillman Cancer Center (HCC) – Cancer Immunotherapeutics Center and an associate professor of medicine at the University of Pittsburgh. Dr. Luke specializes in early phase drug development for solid tumors, particularly novel immunotherapeutics and biomarkers of immunotherapy activity, as well as the management of cutaneous oncology and melanoma. Dr. Luke directs the Translational Immuno-Informatics Laboratory which investigates large scale informatic approaches to advance cancer immunotherapy. Dr. Luke is an active internationally recognized translational investigator leveraging work from his laboratory into more than 10 investigator-initiated, NCI CTEP and/or cooperative group clinical trials and acting as the international PI on registration intent industry studies. Some of these studies have changed the standard of care and are cited in the National Comprehensive Cancer Network guidelines. Dr. Luke has received numerous awards including the Melanoma Research Foundation Humanitarian Award, Crain’s 40 under 40, Department of Defense Career Development Award, Paul Calabresi Career Development in Clinical Oncology Award (K12), ASCO Merit Award as well as Young Investigator Awards from the Melanoma Research Alliance, the Cancer Research Foundation and the Conquer Cancer Foundation of ASCO. Dr Luke has been a review panel member for the NIH R21 and DOD immunotherapy/melanoma grant review panels and has been the ASCO Scientific Committee chair for melanoma. Dr. Luke is currently a senior editor at Clinical Cancer Research, melanoma and skin cancer editor at Cancer as well as the social media (@jasonlukemd) and an associate section editor at the Journal for Immunotherapy of Cancer. Dr. Luke received his M.D. from Rosalind Franklin University of Medicine and Science in Chicago and trained at Boston University Medical Center (Medicine) as well as Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center in New York City (Medical Oncology). Dr. Luke has held prior tenure-track faculty positions at Harvard Medical School and Dana-Farber Cancer Institute as well as the University of Chicago.

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