Kyle Paul Smith, PhD

Kyle Paul Smith, PhD has a diverse work experience spanning various institutions and roles. Kyle Paul began their career as an Intern in Chemical Biology at the University of Cambridge in 2011. Kyle Paul then interned in Medicinal Chemistry at Johns Hopkins Drug Discovery from 2011 to 2012.

In 2015, Kyle worked as an Intern in Early Discovery Biochemistry at Genentech, where they optimized a strategy to incorporate unnatural amino acids into phage displayed peptides and discovered specific binding peptides for epigenetic drug targets.

Kyle pursued their PhD in Structural Biology at Northwestern University - The Feinberg School of Medicine from 2012 to 2018. During their doctoral studies, they solved the crystal structure and generated a multi-domain model of a novel mitochondrial GTPase (Miro) implicated in neurological diseases. Kyle Paul also calculated the NMR structure of a novel mitochondrial-modulating protein (VopE). Additionally, as a Postdoctoral Researcher in Biophysical Characterization at Northwestern University, Kyle led the structural and biophysical characterization of the intrinsically disordered human kinetochore protein (Cdt1) primarily using spectroscopy and scattering techniques. Kyle Paul also established protein purification capabilities in a primarily cell biology lab.

Kyle then joined Takeda as a Scientist in 2019, where they developed MST binding assays for small molecule hit validation of enzyme targets and optimized cIEF for charge profiling of engineered antibody variants and enzyme replacement therapies.

Currently, Kyle is with Xilio Therapeutics, Inc. In their role as a Scientist, they characterized antibody, cytokine, and heterodimeric fusion proteins for stability, purity, and homogeneity. Kyle Paul also won the "X-Nihilo" Team Award for implementing new analytical techniques and contributing to the IL-15 project. Kyle Paul later transitioned to the role of Senior Scientist, leading developability studies as part of the research-to-development transition to the CMC team. Kyle Paul established various stability studies and tested mutations to improve protein properties.

Overall, Kyle's work experience showcases their expertise in protein characterization, structural biology, biophysical techniques, and assay development.

Kyle Paul Smith, PhD has an extensive education history. Kyle Paul obtained their Bachelor of Science degree in Chemical & Biomolecular Engineering from The Johns Hopkins University in 2012. Following this, they pursued a PhD in Life Sciences with a specialization in Protein Biochemistry from Northwestern University - The Feinberg School of Medicine. Kyle Paul completed their doctoral studies in 2018. In 2016, they also received a certificate from Northwestern University - Kellogg School of Management in Management for Scientists & Engineers. In 2022, they further enhanced their leadership skills by earning a certificate in Leadership Essentials from the Cornell University Graduate School.