John W. Eckman

Dr. Greene is the John W. Eckman Professor of Medical Science and Director of Immunobiology and Experimental Pathology Division at the University of Pennsylvania. From 1980 to 1986, he was an Associate Professor at both Harvard University and Harvard Medical School. In 1986, Dr. Greene joined the University of Pennsylvania and became the head of Immunology Research and Professor of Pathology and Laboratory Medicine.

His groundbreaking work in the functions of the human erbB receptors led to the development of Herceptin (Genentech). His research also leads to the development of a proprietary method for the rapid, reliable design of allosteric inhibitors of receptors and enzymes. He has received multiple patents in the area of antibody and mimetic-based cancer therapy, as well as in the engineering of antibody complementary determining regions. He has concentrated on antibody atomic structure and function for the last 30 years.

Dr. Greene\'s laboratory developed an approach to target and down-modulate oncoproteins which when expressed were critical for abnormal malignant cell growth. This simple approach developed in the neu system involved developing monoclonal antibodies specific for the ectodomain of pl85. This was the basis for targeted therapy and the approach has led to improved treatment for early and advanced breast cancer.

Dr. Greene has been recognized with many awards for his work, including Allyn Taylor Prize, Adams County Breast Cancer Research Award, and the Cotlove Award. In 2011 Dr. Greene was made an honorary fellow of Lincoln College, Oxford University.