Sr. Associate Scientist/scientist - Research Pharmacology (temporary)

Alpine Immune Sciences is seeking an enthusiastic and highly motivated Sr. Associate Scientist/Scientist (Temporary) in Immunology or related field to join the Research Pharmacology group. This individual will be responsible for designing and conducting in vivo preclinical pharmacology studies and ex vivo biological sample analyses to help advance our protein-based immunotherapeutics. Excellent written and oral communication skills, as well as strong organizational skills, are essential. Flexibility, adaptability, and a collaborative mindset are also required.   Duties and responsibilities:   • Responsible for the design, development, execution, analysis, and communication of in vivo experiments that will enable therapeutic lead selection, elucidate mechanisms of action, and/or provide the necessary preclinical data to support autoimmune/inflammatory disease indications. • Utilize multi-parameter flow cytometry, ELISA, Luminex, and/or gene expression methodology as critical aspects of preclinical studies. • Participate in cross-functional project teams, collaborate cross-functionally with protein engineering, bioanalytical, and translational colleagues to promote therapeutic candidate advancement. • Interact with external groups, such as contract research organizations and collaborators, to commission work as needed. • Contribute to preclinical study report sections, regulatory submissions and updates; (IND/CTDs, NDA/BLA, DSUR etc.) and abstracts/manuscripts for publication.   Qualifications:   • M.S., B.S., or equivalent experience in immunology, cell biology, pharmacology/drug discovery, and/or associated aspects of immuno-oncology as evidenced by a strong track record in pharmaceutical drug discovery. • Minimum of two years relevant experience (industry experience preferred) • Extensive hands-on experience with in vivo autoimmune/inflammation models and experience developing/optimizing models to evaluate therapeutic candidates across a wide array of therapeutic classes.  • Extensive experience with administration of agents via multiple routes (i.e. intraperitoneal, subcutaneous, oral, and intravenous) and various endpoint assessments such as blood collection, disease scoring, and necropsy. • Must adhere to all local, state and federal guidelines concerning the use of animals in research.   • Experience in authoring and managing IACUC protocols is a plus.  • Independent use of multi-parameter flow cytometry, ELISA’s, and/or Luminex. • Strong problem solver who can thrive in an environment with rapidly changing priorities. • Excellent communication, interpersonal skills, and proven ability to collaborate across multidisciplinary scientific settings. 

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