Senior Scientist, DMPK

About Alterome:

Alterome Therapeutics, Inc. was formed in December 2021 and officially launched operations in January 2022. We are a precision oncology biotech developing alteration-specific therapeutics to address high-value and validated oncogenic drivers. The company is led by a team of experienced leaders with a history of developing marketed oncology small molecule drugs. Alterome recently secured $132 million in Series B funding.

Job Summary:

Alterome is currently seeking an experienced Drug Metabolism and Pharmacokinetics (DMPK) Senior Scientist to support Alterome’s DMPK activities on multiple programs targeting oncology therapeutics. As a DMPK Senior Scientist, you will provide scientific DMPK understandings to ensure that clinical candidates with acceptable drug development characteristics are identified and appropriately characterized and developed. You will play a key role in the discovery and advancement of Alterome’s development compounds and work with Alterome colleagues to participate in all stages of drug property assessments, from compound screening through to IND submissions. You will represent DMPK on Research and Development teams and regularly interface with internal and external colleagues to ensure timely and accurate dissemination of Preclinical Pharmacokinetics.

How You’ll Contribute to the Team…

• Conducting and leading studies independently, analyzing, and interpreting data, and relaying findings to project teams.
• Identifying and understanding the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) characteristics of lead compounds.
• Identifying ADME liabilities for a given scaffold and establish critical path assays to facilitate compound progression in medicinal chemistry.
• Assisting the department's leadership in shaping strategic vision and ensuring efficient departmental operations.
• Serving as a representative for project teams.
• Providing clear communication and interpretation of results to project and leadership teams.

Qualifications:

• An advanced degree in drug metabolism, pharmacokinetics, or a related discipline with a minimum of 5 years’ experience in the biopharmaceutical industry is required.

• Demonstrated ability to design the experiments needed to establish and model PK/PD relationships is required.

• Experience conducting, interpreting, and communicating the results of hands-on experiments and/or those of outsourced ADME assays are essential.

• Experience as DMPK representative working on a CNS drug discovery program is preferred.

• An understanding of CNS drug disposition and transport across the blood-brain barrier is required.

• Experience with hands-on for the in vitro and in vivo DMPK studies is desirable.

• Experience writing study reports, contributing to IND, IB and other regulatory documents is desirable.

• Excellent communication, collaboration, interpersonal, scientific thinking, and problem-solving skills are required.

Who are Alterome Employees?

Although we share varied backgrounds and come with expertise in different areas, we aim to inspire hope for those affected by cancer. Our vision unites us to develop unique therapies that transform the lives of cancer patients, one alteration at a time. Thus, we seek the best people to join this special movement and invest the resources they need to grow, develop, and accomplish our collective goals. We have a passion for what we do and truly enjoy working with each other. In fact, many of us have worked together in multiple companies and there is a genuine camaraderie amongst the group. We would love to bring new faces to the group, and that’s where you come in!

Alterome Offers:

We provide our employees with medical, dental, and vision coverage, life insurance, a 401k w/company matching, competitive compensation (including equity), paid holidays, flexible time off, home office set up, full-service gym on-site (with showers and towel service!), professional development opportunities, phenomenal company culture, and more! Our office is centrally located in San Diego, CA at the intersection of the 15 and 56 Freeways. This is a hybrid role with three days per week in the office required - out of state candidates will not be considered at this time.

Salary Information:  $130,000-$160,000/year based on skills and experience.

EEOC Statement:

Alterome Therapeutics, Inc. is an equal opportunity employer committed to building a diverse and inclusive organization. We measure each applicant, candidate, and employee based on their qualifications for the role, regardless of age, sex, religion, sexual orientation, gender identity, national origin, Veteran status, disability, and/or any other protected class characteristics. Furthermore, Alterome is committed to achieving all business objectives in compliance with all federal, state, and local laws.