Matthias received his PhD from the University of Bonn for his work on protein-ligand docking (FlexX). During research stays with SmithKline Beecham (PA) and Roche Bioscience (CA) he developed the foundations of today’s chemical space technology. In 2002, he became Full Professor for Bioinformatics. His research focusses on the development of novel computational approaches for problems in cheminformatics, structure-based design, and visual chemical analytics. He is Associate Editor of the ACS Journal of Chemical Information and Modeling and elected Vice Chair of the GRC Computer-Aided Drug Design 2021/2023.