Caroline C. Sigman

President & CEO at CCS Associates

Caroline C. Sigman, PhD, President and CEO, founded CCS Associates in 1985. Dr. Sigman has extensive experience in drug development, cancer prevention and treatment, carcinogenesis, and biomarkers. She has served as principal investigator for more than 30 National Institutes of Health (NIH) projects, and has collaborated with government agencies, academia, and the pharmaceutical industry to design development strategies and clinical protocols for the evaluation of molecularly targeted drugs and biomarkers. She has contributed to infrastructure development, agent and biomarker selection, study activation, and management activities for multidrug clinical studies including Master Protocols (“Master INDs”). She has developed criteria for and evaluated cutting-edge translational research projects on biomarkers. Dr. Sigman has authored or coauthored more than 175 journal articles and book chapters and holds a PhD in chemistry/biochemistry.


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