Full-time · Remote · Remote possible
Who We Are Cogent Biosciences is a publicly traded biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogent’s lead therapeutic candidate, bezuclastinib (CGT9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis (SM), which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling. We are currently enrolling two Phase 2 clinical trials for patients with SM and a global Phase 3 trial for GIST patients.
Our Team https://cogent.culturehq.com
The Role:
This is a unique opportunity for a highly motivated, talented and experienced physician to play a key role in designing rational precision therapies that treat the underlying cause of disease to improve patients’ lives. This position will be a key team member in the research and development organization and will be a vital part of helping to achieve the Cogent vision: to discover, develop, and commercialize best-in-class therapies that have a dramatic impact for patients with genetically defined diseases. Cogent is a place where your input matters -- you will have a direct impact on our science and will help to build our capability as a team. You will also shape the Cogent culture and be a part of a passionate, transparent, and collaborative work environment. For the Medical Director role, we are looking for a research-focused physician with clinical expertise to partner with our research teams and provide medical and clinical scientific leadership for potential drug candidates and early development programs, focusing on rationale development of precision small molecules. Industry experience is not required for the Medical Director role; however, experience in the conduct and oversight of clinical studies in academia or industry is preferred. Working on cross-functional multidisciplinary product teams, you will advance promising drug candidates into clinical development and drive the development strategy, the design of clinical trials, and contribute to the execution of the clinical development plan in support of the overall asset strategy. If desired, you may have the opportunity to take on primary medical monitor responsibilities, including oversight of trial subject safety and clinical data review and interpretation, potentially in collaboration with and supported by a clinical scientist, as the program advances.
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